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  • Title: Scopariusols L-T, nine new ent-kaurane diterpenoids isolated from Isodon scoparius.
    Author: Jiang HY, Li XN, Sun HD, Zhang HB, Puno PT.
    Journal: Chin J Nat Med; 2018 Jun; 16(6):456-464. PubMed ID: 30047467.
    Abstract:
    Nine new ent-kaurane diterpenoids, named scopariusols L-T (1-9), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HR-ESI-MS data, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 1 was active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC50 value of 0.6 μmol·L-1.
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