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  • Title: Bona fide receptor for hepatitis B and D viral infections: Mechanism, research models and molecular drug targets.
    Author: Yu Y, Li S, Liang W.
    Journal: Emerg Microbes Infect; 2018 Jul 26; 7(1):134. PubMed ID: 30050063.
    Abstract:
    Hepatitis B infections have become a serious public health issue globally, and the current first-line antiviral treatment for this disease is not a true cure. Recently, sodium taurocholate cotransporting polypeptide (NTCP), a liver-specific bile acid transporter, was identified as a bona fide receptor for hepatitis B virus (HBV) and its satellite virus, hepatitis delta virus (HDV). Identification of the HBV receptor has led to the development of robust cell cultures and provides a potential target for new treatments. This review summarizes the process by which NTCP was discovered and describes its clinical significance as the receptor for HBV and HDV entry.
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