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  • Title: A common precursor for the two subunits of the penicillin acylase from Escherichia coli ATCC11105.
    Author: Oliver G, Valle F, Rosetti F, Gómez-Pedrozo M, Santamaría P, Gosset G, Bolivar F.
    Journal: Gene; 1985; 40(1):9-14. PubMed ID: 3005131.
    Abstract:
    Penicillin acylase (PA) is an industrial enzyme that is used to convert penicillin G into a precursor for semisynthetic penicillins. We have cloned a segment of DNA that codes for the two subunits required for PA activity. We also report the nucleotide sequence of a DNA fragment that codes for (i) the small subunit, (ii) the N-terminal region of the large subunit and (iii) a putative connecting peptide. These results confirm the existence of a common precursor for both peptides.
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