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  • Title: Value of glycolic acid analysis in ethylene glycol poisoning: A clinical case report and systematic review of the literature.
    Author: Tuero G, González J, Sahuquillo L, Freixa A, Gomila I, Elorza MÁ, Barceló B.
    Journal: Forensic Sci Int; 2018 Sep; 290():e9-e14. PubMed ID: 30055870.
    Abstract:
    OBJECTIVE: To evaluate the clinical utility of glycolic acid (GA) determination in the diagnosis and prognosis of ethylene glycol (EG) intoxications. METHOD: Systematic review of serum and/or urine GA concentrations available in the literature in cases of EG poisoning. Present a clinical case in which the determination of the GA was decisive. RESULTS: In total, 137 patients were included. Serum GA concentrations (but not EG) of patients who survive are different from those who die. The optimal cut-off of serum GA to predict mortality was 990.5mg/L (sensitivity 85.2%, specificity 54.3%) with an Odds Ratio of 6.838 (2.868-16.302). In our clinical case, serum EG was negative; however, urine GA was positive (1230.7mg/L). CONCLUSIONS: In all suspected cases of EG poisoning, it is advisable to carry out the simultaneous analysis of EG and GA.
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