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  • Title: Antenatal diagnosis of severe beta thalassemia during the first trimester of pregnancy.
    Author: Trent RJ, Anderson J, Boogert T, Kronenberg H.
    Journal: Pathology; 1985 Oct; 17(4):568-72. PubMed ID: 3005951.
    Abstract:
    Prenatal diagnosis of hemoglobinopathies may be obtained during the first trimester of pregnancy by a combination of chorion biopsy and DNA mapping. This study illustrates 2 DNA approaches which are available for identification of abnormal globin genes. These include restriction fragment length polymorphisms (RFLPs) and direct gene mapping.
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