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  • Title: AMP-insensitive fructose bisphosphatase in Escherichia coli and its consequences.
    Author: Sedivy JM, Babul J, Fraenkel DG.
    Journal: Proc Natl Acad Sci U S A; 1986 Mar; 83(6):1656-9. PubMed ID: 3006063.
    Abstract:
    Inhibition of fructose bisphosphatase (EC 3.1.3.11) by AMP is thought to be an important control mechanism, and, for the Escherichia coli enzyme, is the only control known. We here report on a mutant E. coli fructose bisphosphatase almost insensitive to this inhibition. The purified enzyme is normal in other respects. A strain with this enzyme instead of the wild-type enzyme grows normally in a variety of media. A strain with a very high level of the wild-type enzyme also grows normally. A strain with the very high level of mutant enzyme, however, does show growth abnormalities, but they are not clearly associated with the AMP insensitivity.
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