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  • Title: Analysis of the autophosphorylation activity of transformation defective mutants of avian erythroblastosis virus.
    Author: Hayman MJ, Kitchener G, Knight J, McMahon J, Watson R, Beug H.
    Journal: Virology; 1986 Apr 15; 150(1):270-5. PubMed ID: 3006340.
    Abstract:
    The v-erb B protein of avian erythroblastosis virus (AEV) possesses an associated protein kinase activity in vitro. Analysis of temperature-sensitive mutants, and nonconditional host range mutants of AEV demonstrated that there was no simple correlation between this autophosphorylation activity and the transformation ability of the various AEV mutants. These data suggest that although this kinase activity may be central to transformation by AEV it is in itself insufficient.
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