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  • Title: Changes in topoisomerase I activity after irradiation of lymphoid cells.
    Author: Johnstone A, McNerney R.
    Journal: Biosci Rep; 1985; 5(10-11):907-12. PubMed ID: 3006822.
    Abstract:
    The activity of topoisomerase I in nuclear extracts increased about three-fold 5 min after gamma-irradiation (840-2500 rads) of human peripheral blood lymphocytes or cultured lymphoblastoid cells. The change may reflect modification of the enzyme by nuclear ADP-ribosyl transferase, which is known to be activated by DNA breaks.
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