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  • Title: Effect of 5,7-dihydroxytryptamine on the concentration of individual proteins in different areas of the rat brain.
    Author: Heydorn WE, Creed GJ, Nguyen KQ, Jacobowitz DM.
    Journal: Brain Res; 1986 Mar 12; 368(1):193-6. PubMed ID: 3006866.
    Abstract:
    Proteins which are apparently regulated in concentration in two different areas of the rat brain by the indole neurotransmitter serotonin were identified using two-dimensional gel electrophoresis combined with computerized scanning densitometry. Reduction in central serotonin levels produced a decrease in the concentration of 3 different proteins (2 in the parietal cortex, 1 in the hippocampus). Two proteins, both in the hippocampus, were elevated in concentration following serotonin depletion. These results demonstrate that there exist in the brain a limited number of proteins whose concentration is influenced by serotonin.
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