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  • Title: Risk factors for neonatal group B streptococcus vertical transmission: a prospective cohort study of 1815 mother-baby pairs.
    Author: Chen Z, Wu C, Cao X, Wen G, Guo D, Yao Z, Ye X.
    Journal: J Perinatol; 2018 Oct; 38(10):1309-1317. PubMed ID: 30068969.
    Abstract:
    BACKGROUND: The potential factors associated with group B streptococcus (GBS) vertical transmission have not been studied in detail. STUDY DESIGN: A prospective cohort study was conducted to recruit 1815 mother-neonate pairs for GBS analysis. Pearson's chi-squared tests and generalized linear models were used to explore the risk factors for neonatal GBS colonization. RESULTS: The rate of GBS vertical transmission was 14.1%. GBS colonization in all neonates was significantly associated with maternal GBS colonization, mode of delivery, episiotomy, number of prenatal vaginal exams, parity, and hypertension. For neonates born to GBS-positive mothers, GBS vertical transmission was associated with the mode of delivery, episiotomy, and sexually transmitted diseases. For neonates born to GBS-negative mothers, neonatal GBS colonization was associated with the number of prenatal vaginal exams, parity, and hypertension. CONCLUSION: These findings suggest the need for prenatal GBS screening for pregnant women and intrapartum antimicrobial prophylaxis for GBS-colonized women.
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