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  • Title: Evidence that Con A induces cytotoxicity in the same subclass of T cells as does alloimmunization.
    Author: Falkoff RM, Dutton RW.
    Journal: J Immunol; 1977 May; 118(5):1600-6. PubMed ID: 300750.
    Abstract:
    We have studied the induction of cytoxic activity in murine T cells by the T cell mitogen Con A. Here we report the results of experiments that indicate that this cytotoxicity develops in the same class of T cells potentially activatable to cytotoxicity by immunization with allogeneic cells. Cytotoxic activity does not result from activation of cells of the T-helper class by PHA, and extensive reduction of the proportion of cells of the T-helper class by in vivo treatment with ATS does not comparably reduce the cytotoxicity developed in response to Con A. The Con A-activated cytotoxic cell sediments as a large cell. Furthermore, spleen cell populations previously immunized to alloantigens in vivo develop greatly increased cytotoxicity specific for the alloantigen of the immunizing haplotype after culture with Con A in vitro.
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