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  • Title: HVJ (Sendai virus) stimulates release of interferon from leukocytes used once for interferon production.
    Author: Matsumoto K, Nakamura Y, Akashi K, Yamaguchi H.
    Journal: J Gen Virol; 1986 Apr; 67 ( Pt 4)():809-12. PubMed ID: 3007667.
    Abstract:
    Leukocytes, subjected once to interferon (IFN) induction by HVJ (Sendai virus), were studied for their capability to produce IFN after a second similar stimulus. Substantial amounts of IFN (about 30 000 IU/ml) were recovered. Experiments using cycloheximide or actinomycin D and kinetic studies showed that this IFN originated mainly in IFN which resided within the cell as a result of the first induction and was released after the second stimulation. Increasing amounts of HVJ used for the second stimulus resulted in proportionally increased yields of IFN, reaching a plateau at the same dose of HVJ (1000 HAU/ml) as that which gave optimal yields after the first stimulation. Evidence is presented that the capacity of HVJ to trigger the production of a second IFN harvest is closely associated with its infectivity.
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