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  • Title: Predictive factors of lateral lymph node metastasis in solitary papillary thyroid microcarcinoma without gross extrathyroidal extension.
    Author: Zhang X, Zhang L, Xue S, Wang P, Chen G.
    Journal: Asian J Surg; 2019 Apr; 42(4):563-570. PubMed ID: 30078501.
    Abstract:
    BACKGROUND: Solitary papillary thyroid microcarcinoma (PTMC) without gross extrathyroidal extension (ETE) were the main candidates for active surveillance (AS). Predictive factors of lateral lymph node metastasis (LLNM) in solitary PTMC without gross ETE were essential but still unknown. METHODS: Altogether, 171 patients of solitary PTMC without gross ETE were enrolled in our study and divided into two groups. Group A: 123 patients without lateral lymph node dissection (LLND) were considered to be LLNM negative because there was no lateral recurrence by at least 8-year follow up for all patients. Group B: 48 patients with LLND were considered to be LLNM positive which confirmed by postoperative pathology. RESULTS: Multivariate logistic regression showed male gender, upper location of tumor and diameter of tumor ≥7 mm to be predictive factors (odds ratio = 4.237 [confidence interval (CI) 1.365-13.149, p = 0.012; odds ratio = 2.933 [CI 1.117-7.700, p = 0.029; odds ratio = 4.557 [CI 1383-15.016, p = 0.013) for LLNM in solitary PTMC patients without gross ETE. Multiple level metastasis happened in 29 (60.42%) cases while single level metastasis in 19 (39.58%). Within the lateral cervical lymph node chain, level Ⅲ nodes were consistently the most frequently involved (38/48, 79%), following by level Ⅳ (27/48, 56%), level Ⅱ (25/48, 52%) and level V (5/48, 10%). Most interesting, there are 12 (12/48, 25%) skip metastatic (positive in lateral neck and negative in central neck) patients among LLNM positive group. CONCLUSIONS: Male gender, upper location of tumor and diameter of tumor ≥0.7 cm to be predictive factors of LLNM in solitary PTMC without gross ETE.
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