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Pubmed for Handhelds

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  • Title: Simple Way To Fabricate Novel Paper-Based Valves Using Plastic Comb Binding Spines.
    Author: Han J, Qi A, Zhou J, Wang G, Li B, Chen L.
    Journal: ACS Sens; 2018 Sep 28; 3(9):1789-1794. PubMed ID: 30080022.
    Abstract:
    A novel strategy for fabricating the paper-based valves on microfluidic paper-based analytical devices (μPADs) was described to control fluid in a user-friendly way. Initial prototypes of 3D μPADs manipulate the spatial distribution of fluid within the device. The movable paper channel in a different layer could be achieved using the channel's connection or disconnection to realize the valve function using plastic comb binding spines (PCBS). The entire valve manipulation process was similar to a desk calendar that can be flipped over and turned back. It is notable that this kind of PCBS valve can control a fluid in a simple and easy way without the timing setting or any trigger, and this advantage makes it user-friendly for untrained users to carry out the complex and high throughput operations. The reusable plastic comb binding spines greatly reduce the cost of fabricating paper-based valves. To evaluate the performance, the actual samples of Fe (II) and nitrite were successfully analyzed. We hope this method will introduce a new approach to fabrication of paper-based valves on μPADs in the future.
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