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  • Title: A macromolecular transducer as illustrated by trout hemoglobin IV.
    Author: Brunori M, Coletta M, Giardina B, Wyman J.
    Journal: Proc Natl Acad Sci U S A; 1978 Sep; 75(9):4310-2. PubMed ID: 30085.
    Abstract:
    Oxygen binding by trout Hb IV has been investigated as a function of pH up to 10 atmospheres (1 MPa) of pure O2. The results bring out an extreme proton-oxygen linkage, which gives rise to a Root effect. They are discussed in relation to the function of the hemoglobin as an oxygen pump. The system is of special interest as providing a prototype of a macromolecule acting as a transducer by coupling two allosterically linked reactions.
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