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  • Title: Monoclonal antibody B72.3 as a diagnostic adjunct in fine needle aspirates of breast masses.
    Author: Lundy J, Lozowski M, Mishriki Y.
    Journal: Ann Surg; 1986 Apr; 203(4):399-402. PubMed ID: 3008673.
    Abstract:
    Fine needle aspirations of breast masses were evaluated to establish a cytologic diagnosis. In 45 cases, the sensitivity was 73%, specificity 100%, and diagnostic accuracy 84%. Fifty cases (27 malignant and 23 benign) were evaluated by immunoperoxidase staining of the needle aspirates, using the monoclonal antibody B72.3. Twenty-six of 27 malignant cases stained positively, and 22 of 23 benign cases were negative. The sensitivity was 96%, specificity was 96%, and diagnostic accuracy was 96%. All cases considered malignant cytologically were confirmed by immunocytochemistry. In addition, the B72.3 monoclonal antibody appears to be a valuable diagnostic adjunct in atypical and suspicious cases, particularly those in which hypocellularity and/or cellular monomorphism preclude a diagnosis of malignancy by routine cytologic examination.
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