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  • Title: Immunogenicity and antigenicity of infectious bursal disease virus serotypes I and II in chickens.
    Author: Jackwood DJ, Saif YM, Moorhead PD.
    Journal: Avian Dis; 1985; 29(4):1184-94. PubMed ID: 3008699.
    Abstract:
    Chickens were inoculated with infectious bursal disease virus serotype I or serotype II to determine if their immune system can distinguish between the two serotypes. Chickens had neutralizing antibodies to only serotype I viruses following exposure to serotype I viruses, and chickens had antibodies to only serotype II viruses following exposure to serotype II viruses. No cross-reactions were observed between antisera prepared to each of these two serotypes using a cross-virus-neutralization assay. Signs of disease were detected only in birds exposed to a virulent serotype I isolate. Chicks exposed to the serotype II viruses were not protected from challenge with a virulent serotype I isolate. In one experiment, antibodies to a serotype II isolate, which were detected before challenge, did not protect chicks from challenge with a virulent serotype I isolate.
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