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  • Title: Metabolic and contractile changes in ischaemic rat hearts after isoproterenol administration: effect of reperfusion.
    Author: Bartel S, Krause EG, Karczewski P.
    Journal: Biomed Biochim Acta; 1986; 45(1-2):S215-8. PubMed ID: 3008711.
    Abstract:
    The effect of isoproterenol and of ischaemia followed by reperfusion was studied in isolated perfused rat heart. Whereas after an interval of 5 min of ischaemia the mechanical and biochemical responses to catecholamine were drastically reduced, reperfusion for 1 min normalized the cardiac reactivity. After prolonged ischaemia and reperfusion the hormone-induced rise in cyclic AMP and activation of cyclic AMP dependent protein kinase remains reduced. It is suggested that these changes might be of importance for cardiac protection during a transient ischaemic period.
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