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  • Title: Environmental safety: Air pollution while using MIRUS™ for short-term sedation in the ICU.
    Author: Herzog-Niescery J, Vogelsang H, Gude P, Seipp HM, Uhl W, Weber TP, Bellgardt M.
    Journal: Acta Anaesthesiol Scand; 2019 Jan; 63(1):86-92. PubMed ID: 30088264.
    Abstract:
    BACKGROUND: MIRUS™ is a device for target-controlled inhalational sedation in the ICU in combination with use of isoflurane, or sevoflurane, or desflurane. The feasibility of this device has recently been proven; however, ICU staff exposure may restrict its application. We investigated ICU ambient room pollution during daily work to estimate ICU personnel exposure while using MIRUS™. METHODS: This observational study assessed pollution levels around 15 adult surgical patients who received volatile anaesthetics-based sedation for a median of 11 hours. Measurements were performed by photoacoustic gas monitoring in real-time at different positions near the patient and in the personnel's breathing zone. Additionally, the impact of the Clean Air™ open reservoir scavenging system on volatile agent pollution was evaluated. RESULTS: Baseline concentrations [ppm] during intervention and rest periods were isoflurane c¯mean = 0.58 ± 0.49, c¯max = 5.72; sevoflurane c¯mean = 0.22 ± 0.20, c¯max = 7.93; and desflurane c¯mean = 0.65 ± 0.57, c¯max = 6.65. Refilling MIRUS™ with liquid anaesthetic yielded gas concentrations of c¯mean = 2.18 ± 1.48 ppm and c¯max = 13.03 ± 9.37 ppm in the personnel's breathing zone. Air pollution in the patient's room was approximately five times higher without a scavenging system. CONCLUSION: Ambient room pollution was minimal in most cases, and the measured values were within or below the recommended exposure limits. Caution should be taken during refilling of the MIRUS™ system, as this was accompanied by higher pollution levels. The combined use of air-conditioning and gas scavenging systems is strongly recommended.
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