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  • Title: [Piracetam correction of deficient GABA-ergic inhibition due to early postnatal exposure to cycloheximide].
    Author: Burov IuV, Ostrovskaia RU, Smol'nikova NM, Trofimov SS, Molodavkin GM.
    Journal: Biull Eksp Biol Med; 1986 Apr; 101(4):447-9. PubMed ID: 3008881.
    Abstract:
    Cycloheximide, administered to 7-day-old rats, caused the delay of CNS activity changes in grown-up rats. The animals showed impaired memory function, expressed in the decrease of habituation in the "open field" test, and the alteration of passive avoidance reflex. The increased number of intersignal reactions due to hypermotility was found during elaboration of avoidance reflex. The analysis of evoked potential recovery revealed the deficiency of GABA-ergic inhibition in the neocortex. Piracetam was shown to prevent completely behavioural disturbances and deficiency of GABA-ergic processes in grown-up animals.
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