These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Dibutyryl cyclic guanine monophosphate inhibits natural but not limb amputation-induced motoneurone death in the chick embryo.
    Author: Douglas JH, Ribchester RR.
    Journal: Brain Res; 1986 May; 391(2):271-5. PubMed ID: 3008949.
    Abstract:
    The number and distribution of motoneurones in the lateral motor columns of normal chick embryos have been compared with embryos treated daily with dibutyryl cyclic guanine monophosphate and subject to unilateral limb bud amputation. Treatment with cyclic nucleotide rescued about 17% of the motoneurones compared with controls by Stage 37, but did not prevent amputation-induced motoneurone death. The role of cyclic nucleotides in motoneurone survival is therefore permissive, rather than instructive.
    [Abstract] [Full Text] [Related] [New Search]