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  • Title: The miR-15b-5p/PDK4 axis regulates osteosarcoma proliferation through modulation of the Warburg effect.
    Author: Weng Y, Shen Y, He Y, Pan X, Xu J, Jiang Y, Zhang Q, Wang S, Kong F, Zhao S, Zhou D, Zhang Y.
    Journal: Biochem Biophys Res Commun; 2018 Sep 18; 503(4):2749-2757. PubMed ID: 30093112.
    Abstract:
    Blocking aerobic glycolysis has been proposed as an attractive therapeutic strategy for impairing the proliferation of cancer cells. However, the underlying mechanisms are poorly understood. Here, we show that miR-15b-5p was downregulated in osteosarcoma (OS) and that lower expression of miR-15b-5p promoted proliferation and contributed to the Warburg effect in OS cells. Mechanistically, miR-15b-5p acted as a tumor suppressor in OS by directly targeting pyruvate dehydrogenase kinase-4 and inhibiting its expression. These results reveal a previously unknown function of miR-15b-5p in OS, which is associated with metabolic alterations that promote cancer progression. miR-15b-5p may play an essential role in the molecular therapy of patients with OS.
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