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  • Title: Development of a novel inducer of protein-protein interactions based on aplyronine A.
    Author: Ohyoshi T, Takano A, Namiki M, Ogura T, Miyazaki Y, Ebihara Y, Takeno K, Hayakawa I, Kigoshi H.
    Journal: Chem Commun (Camb); 2018 Aug 21; 54(68):9537-9540. PubMed ID: 30094443.
    Abstract:
    An aplyronine A-swinholide A hybrid, consisting of the macrolactone part of aplyronine A and the side chain part of swinholide A, was designed, synthesized, and evaluated for biological activities. The hybrid retained strong cytotoxicity and actin-depolymerizing activity. In addition, the hybrid induced protein-protein interactions (PPI) between actin and tubulin in the manner of aplyronine A.
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