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  • Title: Site-specific OsO4 modification of the B-Z junctions formed at the (dA-dC)32 region in supercoiled DNA.
    Author: Galazka G, Palecek E, Wells RD, Klysik J.
    Journal: J Biol Chem; 1986 May 25; 261(15):7093-8. PubMed ID: 3009485.
    Abstract:
    OsO4 in the presence of pyridine specifically modifies the structural distortions of the primary helix of supercoiled pRW777 near the (dA-dC)32 sequence. Modification occurs at the same negative superhelix density value as required for formation of the Z-helix within the polymer block. Fine mapping of the distorted regions, which are probably the B-Z junctions, is presented. OsO4 reactions provide a powerful and sensitive chemical approach to study DNA polymorphism in solution.
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