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  • Title: Necrosis of the hepatocytes with hepatitis B surface antigen. Occurrence in a chronic hepatitis B surface antigen carrier.
    Author: Karasawa T, Shikata T.
    Journal: Arch Pathol Lab Med; 1977 Jun; 101(6):280-5. PubMed ID: 301018.
    Abstract:
    Light and electron microscope finding from a liver of a chronic carrier of hepatitis B surface antigen (HBsAg) showed small lymphocytes and macrophages in close contact with liver cells, partial lysis of variable degrees, lytic necrosis, and the complete loss of a few hepatocytes with HBsAg in the cytoplasm. On the basis of these findings, together with the results from immunofluorescence study, the pathogenesis of hepatitis B is discussed, with emphasis on the importance of host cellular immune response. The cytopathic and cytolytic activities of immunologically activated T lymphocytes against liver cells that have antigenic targets associated with HBsAg at their surface and in the cytoplasm are discussed.
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