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  • Title: Combined high-dose intra-arterial and intrathecal chemotherapy for the treatment of a case of extraocular retinoblastoma.
    Author: Rodriguez A, Zugbi S, Requejo F, Deu A, Sampor C, Sgroi M, Bosaleh A, Fandiño A, Schaiquevich P, Chantada G.
    Journal: Pediatr Blood Cancer; 2018 Dec; 65(12):e27385. PubMed ID: 30105793.
    Abstract:
    Patients with retinoblastoma and central nervous system (CNS) involvement are rarely curable with available treatments. We designed a high-dose intra-arterial regimen targeting the ophthalmic artery and chiasm combined with intrathecal chemotherapy to treat a 4-year-old patient with retinoblastoma metastasized to the CNS. After three cycles of this regimen, including carboplatin, melphalan, and intrathecal topotecan, a partial response of the orbital tumor mass and chiasmatic lesion, and complete response in the cerebrospinal fluid and bone marrow were achieved. This new treatment strategy may be explored as a treatment component for patients with overt extraocular retinoblastoma and CNS dissemination.
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