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  • Title: Giant axonal neuropathy: central abnormalities demonstrated by evoked potentials.
    Author: Majnemer A, Rosenblatt B, Watters G, Andermann F.
    Journal: Ann Neurol; 1986 Apr; 19(4):394-6. PubMed ID: 3010802.
    Abstract:
    Previous studies of giant axonal neuropathy have reported clinical and pathological findings that indicate involvement of the central nervous system. We studied 3 boys with giant axonal neuropathy, who were 14 to 16 years of age, using auditory, visual, and somatosensory evoked potentials. Absence of waveforms and prolongation of peak and interwave latencies were found. Abnormalities were noted in all modalities. The auditory brainstem evoked response in particular indicated a significant increase in brainstem conduction time. These studies add clinical neurophysiological confirmation of the central nervous system involvement in this disorder and may also provide a means of quantitative evaluation of its progression.
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