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  • Title: Molecular mechanisms of platelet aggregation.
    Author: Leung L, Nachman R.
    Journal: Annu Rev Med; 1986; 37():179-86. PubMed ID: 3010804.
    Abstract:
    Recent studies suggest that platelet stimulation leads to the induction of specific fibrinogen receptors, which have been identified as the platelet membrane glycoprotein IIb-IIIa complex. The binding of fibrinogen initiates the reversible primary phase of aggregation. With a strong stimulus, thrombospondin is released from the platelet alpha-granules. By interacting with fibrinogen, thrombospondin serves to stabilize the platelet aggregates, which leads to a secondary irreversible phase of aggregation.
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