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  • Title: [Research progress in PRAS40].
    Author: Chen G, Zhu G, Zhang X.
    Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2018 Jun 28; 43(6):685-690. PubMed ID: 30110013.
    Abstract:
    Prolin-rich Akt substrate of 40 kD (PRAS40) is firstly identified as a partner of 14-3-3 protein and a substrate of Akt kinase by Roth et al in 2003. Accumulated evidence shows that PRAS40 is mainly activated by phosphorylate modification at different sites. PRAS40 may be involved in various of signaling pathways, such as mammalian target of rapamycin complex 1 (mTORC1), protein kinase B (Akt), NF-κB and ribosomal protein L11 (RPL11) etc, which can regulate cell proliferation, senescence, autophagy, apoptosis and exosome secretion. 40 kD大小的富含脯氨酸蛋白激酶B(protein kinase B，Akt)底物蛋白(prolin-rich Akt substrate of 40 kD，PRAS40)是2003年Roth等从胞质锚定蛋白14-3-3的伴侣蛋白及Akt激酶的底物中首先鉴定的。PRAS40的活化主要方式为磷酸化修饰，并具有多个磷酸化位点。PRAS40参与调控哺乳动物雷帕霉素靶蛋白复合物1(mammalian target of rapamycin complex 1，mTORC1)，Akt，NF-κB和核糖体蛋白L11(ribosomal protein L11，RPL11)等多条信号通路，影响细胞的增殖、衰老、自噬、凋亡、外泌体分泌等。.
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