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  • Title: New Ansamycins from the Deep-Sea-Derived Bacterium Ochrobactrum sp. OUCMDZ-2164.
    Author: Fan Y, Wang C, Wang L, Chairoungdua A, Piyachaturawat P, Fu P, Zhu W.
    Journal: Mar Drugs; 2018 Aug 15; 16(8):. PubMed ID: 30111735.
    Abstract:
    Two new ansamycins, trienomycins H (1) and I (2), together with the known trienomycinol (3), were isolated from the fermentation broth of the deep-sea-derived bacterium Ochrobactrum sp. OUCMDZ-2164. Their structures, including their absolute configurations, were elucidated based on spectroscopic analyses, ECD spectra, and Marfey's method. Compound 1 exhibited cytotoxic effects on A549 and K562 cell lines with IC50 values of 15 and 23 μM, respectively.
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