These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Development of Antimicrobial and Antifouling Universal Coating via Rapid Deposition of Polydopamine and Zwitterionization.
    Author: Fan YJ, Pham MT, Huang CJ.
    Journal: Langmuir; 2019 Feb 05; 35(5):1642-1651. PubMed ID: 30114915.
    Abstract:
    Biomaterials-associated infections (BAIs) are related to bacterial colonization on medical devices, which lead to a serious medical burden, such as increased healthcare cost, prolonged hospital stays, and high mortality and morbidity. To reduce the risk of infections, in this work, a new approach which makes use of a bioinspired coating with dual antimicrobial and antifouling functions was developed through rapid deposition of functional polydopamine (pDA) and antimicrobial copper ions, and subsequent conjugation of zwitterionic antifouling sulfobetaine (SB) moieties by the aza-Michael addition reaction. pDA permits surface-independent versatile functionalization on a variety of substrates, such as TiO2, SiO2, gold, plastics, and Nitinol alloy. The characterizations for chemical elemental compositions and hydrophilicity by X-ray photoelectron spectroscopy and contact angle goniometer, respectively, indicating the successful grafting of SB moieties and the presence of copper ions in the pDA adlayers. Ellipsometric thicknesses of the thin films were followed to monitor the formation of pDA films and the changes after the post conjugation. UV-vis spectroscopy and inductively coupled plasma-mass spectrometry revealed the coordination structure of catechol-Cu, and release profile of Cu2+ from the constructed functional coatings. The superhydrophilic and charge-balanced SB interface allowed effective resistance of bacterial adsorption. Intriguingly, we scrutinized that the release of bactericidal copper ions enables killing the residual amount of adsorbed bacteria. Moreover, viability tests for fibroblast cells indicate the excellent biocompatibility of the developed medical coatings. For real-world implementation, the antifouling and antimicrobial coatings were applied on commercially available silicone-based urinary catheters, and the existence of bacteria was evaluated by using the plate-counting assay. The results showed an undetectable level of living bacteria. Consequently, the dual functional medical coating offers a promising approach to eliminate BAIs for practical applications.
    [Abstract] [Full Text] [Related] [New Search]