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  • Title: Hydroxyl radicals are not involved in NADPH dependent microsomal lipid peroxidation.
    Author: Bast A, Steeghs MH.
    Journal: Experientia; 1986 May 15; 42(5):555-6. PubMed ID: 3011492.
    Abstract:
    NADPH dependent H2O2 formation in microsomes in the presence of chelated iron leads to formation of hydroxyl radicals. Enhancement of hydroxyl radical generation (via ferric-EDTA or sodium azide) did not result in a concomitant increase in lipid peroxidation; rather, a decrease was observed. Moreover, the hydroxyl radical scavenger DMSO did not inhibit lipid peroxidation. This comparison of hydroxyl radical formation with lipid peroxidation suggests that hydroxyl radicals do not play a part in NADPH-dependent lipid peroxidation.
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