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  • Title: Niridazole suppression of experimental allergic encephalomyelitis in Lewis rats.
    Author: Paterson PY, Harvey JM, Webster LT.
    Journal: J Immunol; 1977 Jun; 118(6):2151-4. PubMed ID: 301156.
    Abstract:
    Administration of niridazole to Lewis rats beginning 2 days before sensitization with guinea pig spinal cord in combination with immunologic adjuvants exerted a dose related suppressive influence on development of experimental allergic encephalomyelitis (EAE). A daily dose of 75 mg/kg completely prevented clinical neurologic signs as well as markedly suppressed occurrence of immunohistopathologic manifestations of this autoimmune disease. A higher daily dose level of niridazole, i.e., 100 mg/k, also inhibited EAE but was associated with neurotoxic manifestations.
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