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  • Title: Effect of forphenicinol on gamma-interferon production in mice sensitized with BCG.
    Author: Okura A, Nakadaira M, Naito K, Ishizuka M, Takeuchi T, Umezawa H.
    Journal: J Antibiot (Tokyo); 1986 Apr; 39(4):569-74. PubMed ID: 3011721.
    Abstract:
    Forphenicinol stimulated the production of BCG-induced gamma-interferon in BCG-sensitized mice as much as 11-fold whereas it did not induce interferon production in unsensitized mice. This stimulatory effect was also observed in mice immuno-suppressed by cyclophosphamide. Furthermore, BCG-induced gamma-interferon production was reduced in mice by treatment with an anti-macrophage agent (silica gel), and forphenicinol administration into such mice could augment their interferon production. Transplantation of macrophages from forphenicinol-treated mice into mice injected with silica gel remarkably enhanced the BCG-induced interferon production in the recipients. These results suggest that the stimulatory effect of forphenicinol on BCG-induced gamma-interferon production in mice was due to the activation of macrophages.
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