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  • Title: Cardiotonic and coronary vasodilatatory effects of amrinone in the canine heart-lung preparation with a support dog as compared with those of dobutamine.
    Author: Takeda K, Matsui K, Nakazawa M, Nakahara H, Imai H, Imai S.
    Journal: Jpn J Pharmacol; 1986 Mar; 40(3):381-8. PubMed ID: 3012165.
    Abstract:
    Analysis of the relative magnitude of the positive inotropic and chronotropic effects and the coronary vasodilating effects of amrinone conducted in the canine heart-lung preparation with a support dog in comparison with those of dobutamine demonstrated that amrinone was a preferential coronary vasodilator rather than a selective positive inotropic agent. An in vitro experiment in the canine papillary muscle suggested the initiation of the slow response action potential as a mechanism of the positive inotropic effect of amrinone.
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