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  • Title: Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice.
    Author: Kurhade C, Schreier S, Lee YP, Zegenhagen L, Hjertqvist M, Dobler G, Kröger A, Överby AK.
    Journal: Emerg Infect Dis; 2018 Sep; 24(9):1709-1712. PubMed ID: 30124404.
    Abstract:
    We compared 2 tick-borne encephalitis virus strains isolated from 2 different foci that cause different symptoms in tick-borne encephalitis patients, from neurologic to mild gastrointestinal symptoms. We compared neuroinvasiveness, neurovirulence, and proinflammatory cytokine response in mice and found unique differences that contribute to our understanding of pathogenesis.
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