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  • Title: Superiority of 2-Level Total Disk Replacement Using a Cervical Disk Prosthesis Versus Anterior Cervical Diskectomy and Fusion.
    Author: Yang W, Si M, Hou Y, Nie L.
    Journal: Orthopedics; 2018 Nov 01; 41(6):344-350. PubMed ID: 30125034.
    Abstract:
    The purpose of this study was to evaluate the superiority of total disk replacement (TDR) using a cervical disk prosthesis vs anterior cervical diskectomy and fusion (ACDF). Ninety-six patients with a diagnosis of degenerative disk disease with radiculopathy or myeloradiculopathy at 2 contiguous levels from C-3 to C-7 were randomly allocated to the TDR group (n=48) or the ACDF group (n=48). Outcome measures were recorded preoperatively and 1 week and 3, 6, 12, 24, and 81 months postoperatively. A total of 80 patients completed the follow-up, including 38 in the TDR group and 42 in the ACDF group. Japanese Orthopaedic Association, visual analog scale, and Neck Disability Index scores showed statistically significant improvement from baseline in both groups. Moreover, compared with the TDR group, the ACDF group had statistically greater visual analog scale scores from 12 months and Neck Disability Index scores from 3 months. Compared with the ACDF group, the TDR group had statistically greater range of motion at both the superior and the inferior treated levels at 3, 6, 12, 24, and 81 months postoperatively. Compared with the TDR group, the ACDF group had statistically greater range of motion at the superior adjacent levels at 6, 12, 24, and 81 months and at the inferior adjacent levels at 24 and 81 months postoperatively. The occurrence of adjacent-segment degeneration at both the superior and the inferior adjacent levels was greater in the ACDF group than in the TDR group. Total disk replacement was safe and effective and a statistically superior alternative to ACDF for degenerative disk disease at 2 contiguous levels. It could reduce the occurrence of adjacent-segment degeneration at the superior and the inferior adjacent segments by reducing the range of motion. [Orthopedics. 2018; 41(6):344-350.].
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