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Pubmed for Handhelds

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  • Title: Fluorescence-guided surgery for high-grade gliomas.
    Author: Lakomkin N, Hadjipanayis CG.
    Journal: J Surg Oncol; 2018 Aug; 118(2):356-361. PubMed ID: 30125355.
    Abstract:
    5-aminolevulinic acid (5-ALA) is a prodrug that results in the fluorescence of high-grade gliomas relative to the surrounding brain parenchyma. 5-ALA has been increasingly utilized in fluorescence-guided surgery for these tumors, and its intraoperative use has been associated with a significantly improved extent of resection and progression-free survival. This review outlines the growing body of evidence that has culminated in the recent Food and Drug Administration approval of 5-ALA, as well as emerging applications for this agent.
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