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  • Title: Peripheral low-density area of hepatic tumors: CT-pathologic correlation.
    Author: Muramatsu Y, Takayasu K, Moriyama N, Shima Y, Goto H, Ushio K, Yamada T, Hasegawa H, Koyama Y, Hirohashi S.
    Journal: Radiology; 1986 Jul; 160(1):49-52. PubMed ID: 3012632.
    Abstract:
    To aid in the distinction between colorectal cancer metastasis to the liver and hepatocellular carcinoma, findings on computed tomographic (CT) scans taken more than 5 minutes after contrast material administration ("late-enhanced CT scans") and pathologic findings were compared. Late-enhanced CT scans of metastatic adenocarcinoma showed a peripheral low-density area (PLDA) that corresponded to viable tumor and a central high-density area that represented fibrous connective tissue. This phenomenon was recognized in 15 of 20 (75%) patients with metastatic adenocarcinoma and in one of 50 (2%) patients with hepatocellular carcinoma. Late-enhanced CT scans may be useful in distinguishing between metastatic nonmucinous colorectal cancer and hepatocellular carcinoma.
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