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  • Title: NaCN inhibits the stereospecific depletion of LTB4 by guinea pig polymorphonuclear leukocytes.
    Author: Pickett WC, Douglas MB.
    Journal: Prostaglandins; 1986 Mar; 31(3):385-94. PubMed ID: 3012651.
    Abstract:
    Caseinate elicited suspension of guinea pig peritoneal PMNs synthesized LTB4, 6t-LTB4, 12-epi-6t-LTB4 and 5HETE after incubations with A23187 and arachidonic acid. Concentrations of LTB4 peaked in 3 minutes and were then rapidly depleted. 6t-LTB4 and 12-epi-6t-LTB4 also peaked in concentrations in 3 min but were depleted slower than LTB4. NaCN inhibited the depletion of LTB4 in a dose dependent fashion without dramatically affecting biosynthesis.
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