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  • Title: The product of the human c-erbB-2 gene: a 185-kilodalton glycoprotein with tyrosine kinase activity.
    Author: Akiyama T, Sudo C, Ogawara H, Toyoshima K, Yamamoto T.
    Journal: Science; 1986 Jun 27; 232(4758):1644-6. PubMed ID: 3012781.
    Abstract:
    Antibodies were raised against a synthetic peptide corresponding to 14 amino acid residues at the COOH-terminus of a protein deduced from the human c-erbB-2 nucleotide sequence. These antibodies immunoprecipitated a 185-kilodalton glycoprotein from MKN-7 adenocarcinoma cells. Incubation of the immunoprecipitates with (gamma-32P)ATP resulted in the phosphorylation of this protein on tyrosine residues. These results indicate that the human c-erbB-2 gene product is the 185-kilodalton glycoprotein that is associated with tyrosine kinase activity. Although the c-erbB-2 protein was predicted to encode a protein very similar to epidermal growth factor (EGF) receptor, EGF did not stimulate this kinase activity either in vivo or in vitro.
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