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  • Title: Scavenger receptor for malondialdehyde-modified high density lipoprotein on rat sinusoidal liver cells.
    Author: Murakami M, Horiuchi S, Takata K, Morino Y.
    Journal: Biochem Biophys Res Commun; 1986 May 29; 137(1):29-35. PubMed ID: 3013183.
    Abstract:
    We report here the presence of a membrane-associated receptor which mediates endocytic uptake of malondialdehyde-modified high density lipoprotein (MDA-HDL) on sinusoidal liver cells. Binding of [125I]MDA-HDL to the cells was followed by internalization and degradation in lysosomes. The binding and lysosomal degradation of [125I]MDA-HDL were effectively inhibited by unlabeled MDA-HDL and acetyl-HDL. However, formaldehyde-treated serum albumin or low density lipoprotein modified either by acetylation or malondialdehyde, ligands known to undergo receptor-mediated endocytosis by sinusoidal liver cells, did not affect the binding of [125I]MDA-HDL to the cells. These results indicate that a receptor for MDA-HDL is described as a distinct member among the scavenger receptors for chemically modified proteins.
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