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  • Title: HTLV-III antibody and T-cell subset ratios in haemophiliacs and their spouses.
    Author: McVerry BA, Machin SJ, Galloway MJ, McCarthy K, Evans P, Barnes RM, Turner GC, Cheingsong-Popov R, Tedder RS, Winter M.
    Journal: Br J Haematol; 1986 Jun; 63(2):347-52. PubMed ID: 3013274.
    Abstract:
    44% of 63 British patients with either haemophilia A or B were HTLV-III antibody positive (HTLV-VIII+). HTLV-III+ was more frequent in high factor VIII concentrate users and 75% of severely affected haemophilia A patients were HTLV-III+. All eight patients who were exposed to factor IX concentrate were HTLV-III-. 17 haemophilia A patients who received only British made factor VIII concentrate (average 12,000 units/year) were HTLV-III-. Two of 63 patients had evidence of a pre-AIDS type symptom complex and both were HTLV-III+. Information from a cohort of 21 Liverpool haemophiliacs suggests that HTLV-III was first introduced into this country in 1981. OKT4/T8 ratios were abnormal in 52% of 21 patients studied but this finding was not confined to either HTLV-III+ or HTLV-III- individuals. The spouses of 14 HTLV-III+ haemophiliacs were all HTLV-III-.
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