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  • Title: Human bone cell cultures: a new model for studying the mechanism of action of calcitonin.
    Author: Fanó G, Maurizi M, Venti-Donti G, Paludetti G, Donti E, Della Torre G.
    Journal: Cell Biochem Funct; 1985 Jul; 3(3):179-84. PubMed ID: 3013447.
    Abstract:
    An investigation on cell cultures obtained from temporal human bone fragments showed that they provide a suitable model for studying the mechanism involved in calcitonin action on bone cells. Furthermore they demonstrated: a transitory increase in 45Ca uptake that returned to control values ten minutes after the hormone was added; a relation between 45Ca uptake and increased cAMP concentrations when these were measured at the same time intervals; a reproduction of the salmon calcitonin (sCT) effect after incubation of the cultures with either db-cAMP or db-cGMP and inhibition of 45Ca uptake and parallel decrease in cAMP levels with propanol. These results suggest that in human bone cell cultures, sCT acts as a temporary promoter of 45Ca uptake, probably by activating an adenylate-cyclase system through a beta-receptor.
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