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  • Title: Cytotoxic p-Terphenyls from the Endolichenic Fungus Floricola striata.
    Author: Xu K, Gao Y, Li YL, Xie F, Zhao ZT, Lou HX.
    Journal: J Nat Prod; 2018 Sep 28; 81(9):2041-2049. PubMed ID: 30137985.
    Abstract:
    Eleven new p-terphenyls, floricolins K-U (1-11), together with 13 biosynthetically related known compounds (12-24) were isolated from an endolichenic fungus, Floricola striata. Their structures were elucidated by extensive spectroscopic analyses and single-crystal X-ray diffraction measurements. The newly isolated p-terphenyls inhibited the growth of A2780, MCF-7, and A549 cell lines. Further evaluation for the multidrug resistance (MDR) reversal activity of compound 5 revealed it enhanced the sensitivity of MCF-7/ADR cells toward adriamycin 39-fold at 10 μM through modulating P-glycoprotein-mediated drug exclusion.
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