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  • Title: Mechanism of phagocytosis of mycobacteria by Schwann cells and their comparison with macrophages.
    Author: Band AH, Chitamber SD, Bhattacharya A, Talwar GP.
    Journal: Int J Lepr Other Mycobact Dis; 1986 Jun; 54(2):294-9. PubMed ID: 3014027.
    Abstract:
    Factors influencing the phagocytosis of mycobacteria by 33B rat Schwannoma cells and rat peritoneal macrophages were studied. Uptake of 14C-acetate-labeled Mycobacterium w by these cells was used to set up a radiometric phagocytosis assay. Incubation at 4 degrees C and treatment with sodium azide (0.2% to 1%), colchicine (10(-7) to 10(-3) M), cytochalasin B (0.2 micrograms/ml to 25 micrograms/ml), and dibutyryl cyclic AMP (10(-7) to 10(-3) M) inhibited the phagocytosis by both cell types in a similar manner. These experiments demonstrate similarities in the mechanism of phagocytosis of mycobacteria by Schwann cells and macrophages.
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