These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: No functional gamma-chain transcripts detected in an alloreactive cytotoxic T-cell clone.
    Author: Rupp F, Frech G, Hengartner H, Zinkernagel RM, Joho R.
    Journal: Nature; ; 321(6073):876-8. PubMed ID: 3014341.
    Abstract:
    Three groups of genes that undergo rearrangements during T-cell maturation have been isolated from T cells. Two of them encode the alpha- and beta-subunits of the T-cell antigen receptor and are shared between antigen-specific, major histocompatibility (MHC) class I-restricted cytotoxic T cells and antigen-specific, MHC class II-restricted helper T cells. The third group of genes, called gamma, is preferentially transcribed in cytotoxic T cells. This led to the hypothesis that the unidentified gamma-gene products could be part of a putative T-cell receptor responsible for MHC class I recognition. We report here on the isolation of three different types of gamma-gene transcripts of an alloreactive cytotoxic T-cell clone (3F9). Two are derived from two rearrangements that have occurred at the same locus (V gamma 10.8A to J gamma 10.5 and transcribed with C gamma 10.5), while the third involves a new V gamma-gene segment that is joined to J gamma 13.4 and transcribed with C gamma 13.4. All these rearrangements are abortive and lead to the formation of non-functional gamma-chain genes because the proper translational reading frame is not maintained. Because the second copy of the C gamma 13.4 gene segment is deleted and as C gamma 7.5 is considered to be a pseudogene and has not undergone any rearrangements in 3F9, we conclude that the alloreactive cytotoxic T-cell clone 3F9 does not contain a functional transcript of a known gamma-chain gene.
    [Abstract] [Full Text] [Related] [New Search]