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  • Title: Effects of intracarotid ionic and non-ionic contrast material on the blood-brain barrier in a rabbit model.
    Author: Wilcox J, Evill CA, Sage MR.
    Journal: Neuroradiology; 1986; 28(3):271-4. PubMed ID: 3014375.
    Abstract:
    A rabbit model was used to assess the effects of intracarotid injections of ionic monomer (meglumine iothalamate), non-ionic monomer (iohexol, iopromide), and non-ionic dimer (iotrol) contrast materials on the blood-brain barrier. The degree of blood-brain barrier damage was assessed qualitatively using Evans' blue dye, and quantitatively by calculating the difference in pertechnetate uptake between injected and non-injected hemispheres. The results showed that the non-ionic dimer, iotrol, had the least effect on the blood-brain barrier, and that although iopromide and iohexol produced greater damage than iotrol, the ionic compound, meglumine iothalamate, caused the greatest disruption to the blood-brain barrier. The implications of these findings are discussed.
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