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  • Title: Chemical constituents from Daphne tangutica and their cytotoxicity against nasopharyngeal carcinoma cells.
    Author: Yin ZY, Cheng YF, Wei JK, Luo XK, Luo P, Liu SN, Xu J, Chen H, Gu Q.
    Journal: Fitoterapia; 2018 Oct; 130():105-111. PubMed ID: 30145333.
    Abstract:
    Two new sesquiterpenoids (1-2), together with 30 known compounds including one sesquiterpenoid (3), six diterpenoids (4-9), fourteen lignans (10-23), and nine other kinds of compounds (24-32), were isolated from the stems of Daphne tangutica Maxim. Their structures were determined through extensive spectroscopic analyses, and the absolute configuration of daphnoid A (1) and B (2) were determined by the experimental and calculated electron circular dichroism (ECD) spectra. All the isolates were evaluated against two human nasopharyngeal carcinoma cells (HONE-1 and SUNE-1). Compound 25 (daphnenone) showed potent cytotoxicity toward HONE-1 and SUNE-1with IC50 values of 2.23 and 1.43 μM, respectively. Further studies indicated that compound 25 exhibited cytotoxic effects by inducing tumor cell apoptosis and arresting the cell cycle at G2/M phases in HONE-1 cells.
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