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  • Title: Correlation between the phenotype and the functional capacity of activated T cells in patients with active systemic lupus erythematosus.
    Author: Volk HD, Kopp J, Körner IJ, Jahn S, Grunow R, Barthelmes H, Fiebig H.
    Journal: Scand J Immunol; 1986 Jul; 24(1):109-14. PubMed ID: 3014641.
    Abstract:
    Activated T cells in the peripheral blood of patients with systemic lupus erythematosus (SLE) were determined using monoclonal antibodies against activation antigens. Elevated percentages of HLA-DR+ T cells were found in association with active disease. In contrast, we observed an increase in IL-2 receptor-bearing T cells in only six out of 16 patients with active disease. In vitro assays, like spontaneous proliferation, response to IL-2, production of IL-2, and immunoglobulin synthesis have shown that the different patterns of activation antigens are related to different functional stages of T-cell activation. The possible therapeutic consequences are discussed.
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